Further studies on platelet adhesiveness and serum cholesteryl linoleate levels in multiple sclerosis.

Earlier work indicated a fall in the level of linoleate, determined by gas chromatography, in the serum of patients in the active phases of multiple sclerosis (Baker, Thompson, and Zilkha, 1964; 1966). In a series of 35 patients with multiple sclerosis the level in the serum of the cholesteryl linoleate fraction, separated by thin-layer chromatography, was reduced in patients with clinical evidence of recent deterioration (Baker, Sanders, Thompson, and Zilkha, 1965).